Severe, spontaneous and persistent pain is usually the indication of a serious problem. Call your dentist immediately to have the situation evaluated. Never exceed the dosage on any prescription or over-the-counter medication. Patients frequently take too much acetaminophen (Tylenol), ibuprofen (Motrin, Advil) and other pain meds, thinking if two don’t work, maybe four will. Read the label on any medication before taking it. Overdosing aspirin or ibuprofen (Advil, Motrin, etc.) can lead to internal bleeding, ulcers, kidney failure, and death. Acetaminophen overdosing is the number one cause of liver failure and liver transplants in the US.